Pseudauchenipterus nodosus is a medium-sized auchenipterid from the Atlantic coastal drainage rivers of eastern Brazil, where it inhabits areas with submerged root systems, leaf litter, and driftwood in moderate- to slow-flowing reaches. Its stout, knobbly head profile and relatively large mouth are adaptations for capturing invertebrates and small prey items from crevices and the substrate surface.
In the aquarium, Pseudauchenipterus nodosus follows the typical auchenipterid pattern of extreme diurnal seclusion followed by nocturnal activity. It requires large, firmly positioned cave hides or hollow logs in which it can rest without being disturbed during the day. Water quality must be maintained consistently, as it is somewhat less forgiving than some other driftwood catfish.
This species is peaceful with appropriately sized tankmates and can be housed in large South American community tanks alongside medium tetras, cichlids, and other catfish. Feed after dark with sinking pellets, frozen prawns, bloodworm, and earthworms. Its unusual head morphology and bold nocturnal behaviour make it an interesting species for the intermediate catfish enthusiast.