Otocinclus mangaba was described from river systems draining the Cerrado biome of central Brazil — one of the world's most biodiverse savanna ecosystems, characterised by highly seasonal rainfall and streams that range from raging torrents in the wet season to gentle trickles in the dry. The species name mangaba refers to a native Cerrado fruit tree, reflecting the locality of the type specimens.
The streams of the Brazilian Cerrado that O. mangaba inhabits are typically clear, warm, and nutrient-poor, with soft to moderately hard water and sandy or rocky substrates. This species, like all otocinclus, is a periphyton grazer that forages in loose schools, maintaining its position in moderate current using its adhesive ventral disc. The Cerrado's seasonal hydrology means this species may be adapted to some degree of variation in water level, temperature, and chemistry.
In the aquarium, O. mangaba is a rewarding species for hobbyists interested in Cerrado biotopes or simply want a less common otocinclus with a scientific story to tell. Care requirements are standard: excellent water quality, group housing, and reliable supplemental feeding. Its warm-water preference aligns well with tropical planted aquarium conditions.